您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Mecillinam
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Mecillinam
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mecillinam图片
规格:98%
分子量:325.4
包装与价格:
包装价格(元)
10mg电议
100mg电议

产品介绍
Mecillinam (Amdinocillin) 是一种 β-内酰胺类抗生素,对革兰氏阴性菌具有广谱活性。
货号:ajcx20244
CAS:32887-01-7
分子式:C15H23N3O3S
分子量:325.4
溶解度:Chloroform: 30 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Mecillinam is a β-lactam antibiotic.1 It is active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively). It is also active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine.2 It binds to K. pneumoniae penicillin-binding protein 2 (PBP2) over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = <0.0075, >256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay.3 Mecillinam is efficacious against susceptible E. coli strains in a systemic mouse model of infection with 50% protective dose (PD50) values ranging from less than or equal to 0.39 to 6.4 mg/kg.4


|1. Neu, H.C. Amdinocillin: A novel penicillin. Antibacterial activity, pharmacology and clinical use. Pharmacotherapy 5(1), 1-10 (1985).|2. Fuchs, F., and Hamprecht, A. Results from a prospective in vitro study on the mecillinam (amdinocillin) susceptibility of Enterobacterales. Antimicrob. Agents Chemother 63(4), e02402-02418 (2019).|3. Sutaria, D.S., Moya, B., Green, K.B., et al. First penicillin-binding protein occupancy patterns of β-lactams and β-lactamase inhibitors in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 62(6), e00282-00218 (2018).|4. Anderson, J.D., Eftekhar, F., Cleeland, R., et al. Comparative activity of mecillinam and ampicillin singly and in combination in the urinary bladder model and experimental mouse model. J. Antimicrob. Chemother. 8(2), 121-131 (1981).