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Glp-Amyloid-β(3-40)Peptide(human)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glp-Amyloid-β(3-40)Peptide(human)(trifluoroacetate salt)图片
包装:100ug
规格:98%
市场价:10001元
分子量:4125.7

产品介绍
C187H283N51O53S.XCF3COOH
货号:ajcx19446
CAS:N/A
分子式:C187H283N51O53S.XCF3COOH
分子量:4125.7
溶解度:Formic Acid: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Glp-Amyloid-β (3-40) peptide is a fragment of amyloid-β (1-40) that contains the cyclic amino acid pyroglutamate at the N-terminus. Glp-Amyloid-β (3-40) peptide is a major component of the endogenous amyloid-β content in post-mortem brain tissue from patients with Alzheimer's disease.1 It is formed through cleavage of the N-terminal aspartate and alanine on Aβ40 and Aβ42 followed by dehydration of glutamic acid by glutaminyl cyclase.2 Glp-Amyloid-β (3-40) peptide has been used as a reference peptide for the quantification of total pyroglutamate amyloid-β in APP23 mouse brain.1

参考文献
1. Schieb, H., Kratzin, H., Jahn, O., et al. β-Amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice. Comparison with human Alzheimer amyloid. J. Biol. Chem. 286(39), 33747-33758 (2011).
2. Jawhar, S., Wirths, O., and Bayer, T.A. Pyroglutamate amyloid-β (Aβ): A hatchet man in Alzheimer disease. J. Biol. Chem. 286(45), 38825-38832 (2011).