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Ciclesonide-d7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ciclesonide-d7图片
规格:98%
分子量:547.7
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
C32H37D7O7
货号:ajcx19352
CAS:1225382-70-6
分子式:C32H37D7O7
分子量:547.7
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ciclesonide-d7 is intended for use as an internal standard for the quantification of ciclesonide by GC- or LC-MS. Ciclesonide is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).1 CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.2 It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.

参考文献
1. Derendorf, H., Nave, R., Drollmann, A., et al. Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma. Eur. Respir. J. 28(5), 1042-1050 (2006).
2. Belvisi, M.G., Bundschuh, D.S., Stoeck, M., et al. Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma. J. PHarmacol. Exp. Ther. 314(2), 568-574 (2005).