| 规格: | 98% |
| 分子量: | 468.6 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 10mg | 电议 |
| 5mg | 电议 |
Background:
4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and<1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.
参考文献
1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).
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