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TC 14012(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TC 14012(trifluoroacetate salt)图片
规格:98%
分子量:2066.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
C-X-C chemokine receptor type 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 which is designated as chemokine ligand 12 (CXCL12).
货号:ajcx19012
CAS:N/A
分子式:C90H140N34O19S2•XCF3COOH
分子量:2066.4
溶解度:DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

C-X-C chemokine receptor type 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis. TC 14012 is an antagonist of CXCR4, blocking CXCR4-mediated HIV infection with an IC50 value of 19.3 nM. In addition, TC 14012 (100 μg/ml) inhibits CXCL12-induced phosphorylation of p42/44 MAPK and STAT3 in B cells from patients with chronic lymphocytic leukemia. This peptidomimetic is C-terminally amidated, resulting in high stability in serum. TC 14012 also activates CXCR7 (EC50 = 350 nM), resulting in the recruitment of β-arrestin and Erk ½ phosphorylation.