您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > C2 Phytoceramide(t18:0/2:0)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
C2 Phytoceramide(t18:0/2:0)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C2 Phytoceramide(t18:0/2:0)图片
包装:5mg
规格:98%
市场价:2245元
分子量:359.6

产品介绍
C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells.
货号:ajcx18184
CAS:N/A
分子式:C20H41NO4
分子量:359.6
溶解度:DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 µM) in suspended polymorphonuclear cells. It increases COX-2 protein levels 15-fold through ERK signaling. It induces death of keratinocytes (20% viability) with an ED50 value of 30 µM, the same concentration at which 35% of cells in a TUNEL assay are apoptotic. C2 Phytoceramide also has antiproliferative effects in CHO cells, with greater than 80% cytotoxicity achieved at a concentration of 20 µM, and induces internucleosomal DNA fragmentation. In addition, it inhibits the activation of phospholipase D (PLD) mediated by muscarinic acetylcholine receptors in vitro.