(2R,3S)-E1R (Compound 2c) 是 E1R 的一种对映异构体。(2R,3S)-E1R 是 sigma-1 受体的正变构调节剂 (Sig1R PAM)，可用于治疗认知和记忆障碍。
货号:ajcx15212
CAS:1424832-60-9
分子式:C13H16N2O2
分子量：232.28
溶解度:DMSO: 250 mg/mL (1076.29 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].

Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer's disease, major depressive disorders, and schizophrenia[1].

[1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71.