LTX-401 is an immunotherapeutic agent and an oncolytic amino acid analogue with potential immunogenic properties. LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma. The cytotoxic effect of LTX-401 was attenuated by the double knockout of BAX and BAK, as well as the mitophagy-enforced depletion of mitochondria, yet was refractory to caspase inhibition. LTX-401 induced all major hallmarks of immunogenic cell death detectable with biosensor cell lines including calreticulin exposure, ATP release, HMGB1 exodus and a type-1 interferon response. Moreover, LTX-401-treated tumors manifested a strong lymphoid infiltration. LTX-401 can stimulate immunogenic cell death through a pathway in which Golgi-localized LTX-401 operates upstream of mitochondrial membrane permeabilization. References: Eike LM, Mauseth B, Camilio KA, Rekdal O, Sveinbjornsson B. The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma. PLoS One. 2016 Feb 16;11(2):e0148980. doi: 10.1371/journal.pone.0148980. PubMed PMID: 26881822; PubMed Central PMCID: PMC4755540.

纯度：≥98%

CAS：1398051-86-9