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PF-03654746 Tosylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-03654746 Tosylate图片
规格:98%
分子量:494.59
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
PF-03654746 Tosylate (PF-03654746) 是一种有效的选择性组胺 H3 receptor 拮抗剂,具有脑渗透性。PF-03654746 Tosylate (PF-03654746) 可减少过敏原引起的鼻炎反应。PF-03654746 Tosylate (PF-03654746) 用于治疗人类认知障碍,改善阿尔茨海默病人 (AD) 的认知。
货号:ajcx14966
CAS:1039399-17-1
分子式:C25H32F2N2O4S
分子量:494.59
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].


[1]. Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. [2]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.