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Jatrorrhizine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Jatrorrhizine图片
规格:98%
分子量:338.38
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Jatrorrhizine 是一种有效的口服活性 uptake-2 transporter 抑制剂,可以从各种中药植物中分离出来。 Jatrorrhizine 通过抑制 HT22 海马神经元中的 MAPK 途径,在 H2O2 诱导的细胞凋亡中发挥关键的神经保护作用。
货号:ajcx14778
CAS:3621-38-3
分子式:C20H20NO4+
分子量:338.38
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Jatrorrhizine is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2].

Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters[1].Jatrorrhizine significantly inhibits the plasma membrane monoamine transporter (PMAT) -mediated MPP+ uptake in a concentration-dependent manner with an IC50 value of 1.05 μM[1].Jatrorrhizine demonstrates a more powerful inhibition on serotonin (5-HT) and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT[1].Jatrorrhizine attenuates the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons[2].


[1]. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.