Men 10376 TFA 是一种有效的选择性的 tachykinin NK-2 受体拮抗剂，对大鼠小肠 NK-2 受体的 Ki 值为 4.4 μM。
货号:ajcx14002
CAS:N/A
分子式:C59H69F3N12O12
分子量：1195.25
溶解度:H2O: 1.43 mg/mL (1.20 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor[1]. Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1]

Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].

Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].

[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36. [2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8.