BRM/BRG1ATPInhibitor-1是一种变构brahma同系物(BRM)/SMARCA2(SWI/SNF相关的染色质亚家族成员2的基质相关肌动蛋白依赖调节因子)和brahma相关基因1(BRG1)/SMARCA4三磷酸腺苷酶活性双抑制剂，IC50值均低于0.005μM。
货号:ajcx13636
CAS:2270879-17-7
分子式:C11H9F3N4O2S
分子量：318.27
溶解度:DMSO: 250 mg/mL (785.50 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 &#181M[1]. IC50: ﹤0.005 &#181M (BRM, BRG1)[1]

参考文献：
[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172