Loviride(R89439)是一种非核苷类逆转录酶抑制剂(NNRTI)，对HIV-1逆转录酶的IC50值为0.3µM。Loviride(R89439)可抑制MT-4细胞中的HIV-1，HIV-2和SIV复制。
货号:ajcx12792
CAS:147362-57-0
分子式:C17H16Cl2N2O2
分子量：351.23
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC50s of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells[1].

Loviride (0.01 µM) inhibits HIV-1(IIIB) replication in MT-4 cells, also inhibits HIV-2 and SIV, with EC50s of 85.5, 7.4 µM for HIV-2 (ROD), HIV-2 (EHO), and 11.4, 28.5, 57.0 µM for SIV (mac251), SIV (agm3), SIV (mndGB1), respectively[1].

[1]. Witvrouw M, et al. Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV. AIDS. 1999 Aug 20;13(12):1477-83.