Durlobactamsodiumsalt(ETX2514)是一种广谱β-内酰胺酶(β-lactamase)抑制剂，抑制A类酶KPC-2，C类酶AmpC和D类酶OXA-24，IC50分别为4,14和190nM。可用于治疗耐药性的革兰氏阴性菌，包括Acinetobacterbaumannii。
货号:ajcx12788
CAS:1467157-21-6
分子式:C8H10N3NaO6S
分子量：299.24
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii[1].

[1]. Durand-Réville TF, et al. ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Nat Microbiol. 2017 Jun 30;2:17104.