您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Rovanersen
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Rovanersen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
规格:98%
分子量:6617
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Rovanersen (WVE-120101) 是一种反义寡核苷酸,通过特异靶向 huntingtin (HTT) 基因的突变mRNA拷贝,而不影响正常的 HTT基因的mRNA,从而防止有缺陷的 huntingtin 蛋白的产生。Rovanersen 可用于亨廷顿病的研究。
货号:ajcx38438
CAS:2072901-32-5
分子式:N/A
分子量:6617
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of HTT gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen can be used for huntington's disease research[1].

In vitro, Rovanersen (WVE-120101) leads to the selective RNase H cleavage of mutant Huntingtin allele (mHTT) over wtHTT, with no complement activation. Rovanersen selectively decreases mHTT mRNA and protein levels compared with wtHTT in multiple cells lines[1].

In non-human primates (NHPs), Rovanersen (WVE-120101) is found in nuclear and perinuclear compartments of neurons in brain areas believed to be involved in HD pathology[1].

[1]. M Meena, et al. Selectivity and Biodistribution of WVE-120101, a Potential Antisense Oligonucleotide Therapy for the Treatment of Huntington's Disease (S56.001). AAN Enterprises. April 18, 2017; 88 (16 Supplement).