Pepinh-TRIF (TFA) 是一种 30 aa 肽，通过干扰 TLR-TRIF 的相互作用 (TLR-TRIF interaction ) 来阻断 TRIF 信号。
货号:ajcx37710
CAS:N/A
分子式:C180H279F3N58O40S2
分子量：4016.63
溶解度:H2O : 50 mg/mL (12.45 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction[1].

Pepinh-TRIF (40 μM, 6 hours) blocks the expression and production of IL-33 stimulated by polyI:C or flagellin, and also greatly suppresses the stimulated IκB-α phosphorylation and degradation in HCECs[1].Pepinh-TRIF (40 μM, 6 hours) suppresses NF-κB activation with p65 protein nuclear translocation [1].

[1]. Amal Hasan, et al. TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation. Int J Mol Sci. 2019 Aug 23;20(17):4112.