LP99 (LP-99) is a first-in-class BRD7/9 bromodomain inhibitor (Kd = 99 nM for BRD9) with anti-inflammatoryr activity. It inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner. The effect of LP99 on IL-6 expression demonstrates for the first time that a small-molecule BRD7/9 inhibitor may have a similar function and utility to IL-6 neutralizing antibodies, such as tocilizumab, in the treatment of rheumatoid arthritis.

纯度：≥98%

CAS：1808951-93-0