PF-00835231 是一种冠状病毒主要蛋白酶 3CLpro 的抑制剂，对 SARS CoV-2 和 SARS CoV-1 3CLpro 作用的 IC50 值分别为 0.27 nM 和 4 nM。PF-00835231 被开发用于抗 SARS-CoV-2/COVID-19 的研究。
货号:ajcx33118
CAS:870153-29-0
分子式:C24H32N4O6
分子量：472.53
溶解度:DMSO : 250 mg/mL (529.07 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively. PF-00835231 is developed for the research of anti-SARS-CoV-2/COVID-19[1].

[1]. Robert L Hoffman, et al. Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19. J Med Chem. 2020 Nov 12;63(21):12725-12747.