您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Lanicemine dihydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Lanicemine dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lanicemine dihydrochloride图片
规格:98%
分子量:271.19
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Lanicemine (AZD6765) dihydrochloride 是一种低捕获的 NMDA 受体拮抗剂,Ki 为 0.56-2.1 µM。CHO 和爪蟾卵母细胞中,IC50 分别为 4-7 µM 和 6.4 µM。具有抗抑郁作用。
货号:ajcx32560
CAS:153322-06-6
分子式:C13H16Cl2N2
分子量:271.19
溶解度:DMSO : 240 mg/mL (884.99 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 µM for NMDA receptor; IC50s of 4-7 µM and 6.4 µM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].


Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1].

参考文献:
[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.