IRBP(1-20),humanTFA包含H-2b单倍型的主要表位。IRBP(1-20),humanTFA诱导H-2b小鼠实验性自身免疫性葡萄膜视网膜炎(EAU)。
货号:ajcx31888
CAS:N/A
分子式:C103H165F3N24O30S
分子量：2308.62
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IRBP (1-20), human TFA contains a major epitope for the H-2b haplotype. IRBP (1-20), human TFA induces experimental autoimmune uveoretinitis (EAU) in H-2b mice[1][2].

IRBP (1-20), human TFA induces EAU[2].For determination of proliferative and cytokine responses, lymph node and spleen cells are collected 21 days after immunization and are stimulated in culture with the appropriate antigen. Cells of C57BL/6 mice and 129/J mice immunized with IRBP (1-20), human TFA proliferated in response to the peptide[2]. Animal Model: C57BL/6 (H-2b) mice, H-2b (C57BL/6, 129/J) mice[2]

[1]. Avichezer D, et al. Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice. Exp Eye Res. 2000;71(2):111‐118. [2]. Avichezer D, Silver PB, Chan CC, Wiggert B, Caspi RR. Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci. 2000;41(1):127‐131.