Tecalcet (KRN-568; NPS-R-568; R-568) is a novel, potent, orally bioactive calcimimetic compound/calcium channel agonist that can be potentially used for the treatment of hyperparathyroidism, postmenopausal symptom. It allosterically and positively modulates the calcium-sensing receptor (CaSR). NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism.NPS R-568 decreases plasma PTH in rats with mild and severe renal or dietary secondary hyperparathyroidism. NPS R-568 halts or reverses osteitis fibrosa in uremic rats.

纯度：≥98%

CAS：177172-49-5