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(±)-N-desmethyl Venlafaxine(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-N-desmethyl Venlafaxine(hydrochloride)图片
规格:98%
分子量:299.8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A minor active metabolite of venlafaxine
货号:ajcx26666
CAS:93413-90-2
分子式:C16H25NO2 ? HCl
分子量:299.8
溶解度:Chloroform: slightly soluble,DMSO: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

(±)-N-desmethyl Venlafaxine is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.1It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP3A4.2(±)-N-desmethyl Venlafaxine inhibits norepinephrine and serotonin reuptake in rat synaptosome preparations (IC50s = 4.7 and 1.6 µM, respectively).1In vivo, (±)-N-desmethyl venlafaxine reverses reserpine-induced hypothermia in mice with a minimum effective dose (MED) of 10 mg/kg.

1.Muth, E.A., Moyer, J.A., Haskins, J.T., et al.Biochemical, neurophysiological, and behavioral effects of Wy-45,233 and other identified metabolites of the antidepressant venlafaxineDrug Dev. Res.23(2)191-199(1991) 2.Otton, S.V., Ball, S.E., Cheung, S.W., et al.Venlafaxine oxidation in vitro is catalysed by CYP2D6Br. J. Clin. Pharmacol.41(2)149-156(1996)