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2&prime-C-β-Methylguanosine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2&prime-C-β-Methylguanosine图片
规格:98%
分子量:297.3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An active nucleoside metabolite of BMS-986094
货号:ajcx26566
CAS:374750-30-8
分子式:C11H15N5O5
分子量:297.3
溶解度:DMF: 2 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

2’-C-β-Methylguanosine is an active nucleoside metabolite of the antiviral prodrug BMS-986094.1It inhibits replication in genotype 1b hepatitis C virus (HCV) replicon cells (EC50s = 5.2 and 3.2 µM in ELISA and luciferase assays, respectively).22’-C-β-Methylguanosine also inhibits replication of the Zika virus clinical isolate ZIKVPE243in infected human brain microvascular endothelial cells (HBMECs), SH-SY5Y cells, and Vero cells (EC50s = 0.88, 2.09, and 1.25 µM, respectively) but is toxic to mice infected with ZIKVPE243at postnatal day 2 when administered at a dose of 25 mg/kg per day.3

1.Liu, A., Lute, J., Gu, H., et al.Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MSJ. Chromatogr. B Analyt. Technol. Biomed. Life Sci.100029-40(2015) 2.Sizun, G., Pierra, C., Peyronnet, J., et al.Design, synthesis and antiviral evaluation of 2’-C-methyl branched guanosine pronucleotides: The discovery of IDX184, a potent liver-targeted HCV polymerase inhibitorFuture Med. Chem.7(13)1675-1700(2015) 3.Matos de Souza, M.R., Cunha, M.S., Okon, A., et al.In vitro and in vivo characterization of the anti-Zika virus activity of ProTides of 2’-C-β-methylguanosineACS Infect. Dis.6(7)1650-1658(2020)