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Brevetoxin 3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Brevetoxin 3图片
包装:100ug
规格:98%
市场价:5186元
分子量:897.1

产品介绍
Brevetoxin 3 (PbTx-3) 是一种有效的变构电压门控 Na+ 通道激活剂,具有多个活性中心(A 环内酯,R 侧链的 C-42)。
货号:ajcx26408
CAS:85079-48-7
分子式:C50H72O14
分子量:897.1
溶解度:DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:


Brevetoxin 3 is a neurotoxin produced by the dinoflagellateK. brevis.1,2It binds to site 5 of voltage-gated sodium channels (Navs), prolonging the mean open time and inhibiting inactivation of these channels.2Brevetoxin 3 induces the release of lactate dehydrogenase (LDH), L-glutamate, and L-aspartate from primary rat cerebellar granule neurons (CGNs; EC50s = 30.9, 45.3, and 50.2 nM, respectively).3It induces convulsions in, and is lethal to (LD50= 4 ng/egg), Japanese rice fish embryos.1Brevetoxin 3 has been found in water samples collected during red tide blooms.4


1.Colman, J.R., and Ramsdell, J.S.The type B brevetoxin (PbTx-3) adversely affects development, cardiovascular function, and survival in Medaka (Oryzias latipes) embryosEnviron. Health Perspect.111(16)1920-1925(2003) 2.Jeglitsch, G., Rein, K.S., Baden, D.G., et al.Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neuronsJ. Pharmacol. Exp. Ther.284(2)516-525(1997) 3.Berman, F.W., and Murray, T.F.Brevetoxins cause acute excitotoxicity in primary cultures of rat cerebellar granule neuronsJ. Pharmacol. Exp. Ther.290(1)439-444(1999) 4.Pierce, R.H., and Henry, M.S.Harmful algal toxins of the Florida red tide (Karenia brevis): Natural chemical stressors in South Florida coastal ecosystemsEcotoxicology17(7)623-631(2008)