您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > 5α-Androstan-3β-ol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
5α-Androstan-3β-ol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5α-Androstan-3β-ol图片
规格:98%
分子量:276.5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
A steroidal androgen
货号:ajcx26028
CAS:1224-92-6
分子式:C19H32O
分子量:276.5
溶解度:Chloroform: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:


5α-Androstan-3β-ol is a steroidal androgen.1It binds to the androgen receptor in a cell-free assay (IC50= 1.7 µM) and activates the pregnane X receptor (PXR) in HepG2 cells in a reporter assay (EC50= 0.8 µM).1,25α-Androstan-3β-ol also inhibits the androst-4-ene-3,17-dione hydroxylase activities of 16α- and 6β-hydroxylase but not 16β- or 7α-hydroxylase (IC50s = 70, 110, >150, and >150 µM, respectively).3It decreases testis weight and sperm production in mice when administered at a dose of 30 mg/kg.4


1.Fang, H., Tong, W., Branham, W.S., et al.Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptorChem. Res. Toxicol.16(10)1338-1358(2003) 2.Ekins, S., Chang, C., Mari, S., et al.Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sitesMol. Pharmacol.72(3)592-603(2007) 3.Murray, M., and Mehta, I.Structure-activity relationships in the in vitro modulation of rat hepatic microsomal androst-4-ene-3,17-dione hydroxylase activities by derivatives of 5α- and 5β-androstaneJ. Steroid Biochem.35(3-4)465-471(1990) 4.Martinot, E., Baptissart, M., VÉga, A., et al.Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalphaSci. Rep.742182(2017)