A metabolite of p-cresol
货号:ajcx25784
CAS:17680-99-8
分子式:C13H16O7
分子量：284.3
溶解度:Ethanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

p-Cresol glucuronide is a metabolite ofp-cresol, a uremic toxin formed by bacterial fermentation of proteins in the large intestine.¹It is formed fromp-cresol primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A6, but also by UGT1A9, in human liver and kidney microsomes.p-Cresol glucuronide accumulates in feces, blood, and urine of patients with chronic kidney disease (CKD).²

1.Rong, Y., and Kiang, T.K.L.Characterizations of human UDP-glucuronosyltransferase enzymes in the conjugation of p-cresolToxicol. Sci.176(2)285-296(2020) 2.Gryp, T., De Paepe, K., Vanholder, R., et al.Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney diseaseKidney Int.97(6)1230-1242(2020)