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NSC 756093
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NSC 756093图片
规格:98%
分子量:337.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
NSC 756093 是一种有效的 GBP1:PIM1 相互作用抑制剂。 NSC 756093 可以潜在地恢复对紫杉醇的耐药性。 NSC 756093 可用于卵巢癌研究。
货号:ajcx25780
CAS:1629908-92-4
分子式:C20H19NO4
分子量:337.4
溶解度:DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

NSC 756093 is an inhibitor of the protein-protein interaction between guanylate binding protein 1 (GBP1) and the serine/threonine kinase Pim-1.1It binds to GBP1-Pim-1 (Kd= 38 nM) and inhibits the interaction by 65% when used at a concentration of 100 nM. NSC 756093 enhances radiation-induced cytotoxicity in FaDu hypopharyngeal carcinoma cells (IC50= 496 nM), as well as induces apoptosis and cell cycle arrest at the G2/M phase in the same cells.2


1.Andreoli, M., Persico, M., Kumar, A., et al.Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cellsJ. Med. Chem.57(19)7916-7932(2014) 2.Resendez, A., Tailor, D., Graves, E., et al.Radiosensitization of head and neck squamous cell carcinoma (HNSCC) by a podophyllotoxinACS Med. Chem. Lett.10(9)1314-1321(2019)