A 5-HT6 receptor antagonist
货号:ajcx25518
CAS:N/A
分子式:C12H16N6O2S·2HCl [XH2O]
分子量：381.3
溶解度:DMSO: 15 mg/ml,Water: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ro 04-6790 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT₆(K_i= 44.7 nM).¹It is selective for 5-HT₆receptors over a panel of 23 additional receptors at 10 µM. Ro 04-6790 inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT₆(pA₂= 6.75).In vivo, Ro 04-6790 (10 and 30 mg/kg) induces stretching and yawning behavior in rats. It reverses scopolamine-induced decreases in novel object discrimination in rats.²Ro 04-6790 (3, 10, and 30 mg/kg) also attenuates cue-induced cocaine-seeking behavior in rats.³

1.Sleight, A.J., Boess, F.G., BÖs, M., et al.Characterization of Ro 04-6790 and Ro 63-0563: Potent and selective antagonists at human and rat 5-HT6 receptorsBr. J. Pharmacol.124(3)556-562(1998) 2.Woolley, M.L., Marsden, C.A., Sleight, A.J., et al.Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790Psychopharmacology (Berl)170(4)358-367(2003)