| 规格: | 98% |
| 分子量: | 372.9 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
Background:
Metolazone-d7is intended for use as an internal standard for the quantification of metolazone by GC- or LC-MS. Metolazone is a thiazide-like diuretic.1,2It inhibits the Na+/Cl-cotransporter (IC50= 0.3 µM for the rat transporter) and human carbonic anhydrase VII (CAVII), CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively). Metolazone (0.3 and 1 mg/kg) induces fluid loss and enhances captopril-induced decreases in blood pressure in spontaneously hypertensive rats.3Formulations containing metolazone have been used in the treatment of high blood pressure.
1.Moreno, E., CristÓbal, P.S., Rivera, M., et al.Affinity-defining domains in the Na-Cl cotransporter: A different location for C- and thiazide bindingJ. Biol. Chem.281(25)17266-17275(2006) 2.Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adductBioorg. Med. Chem. Lett.18(8)2567-2573(2008) 3.Chiu, P.J.S., Vemulapalli, S., and Barnett, A.Acute blood pressure and urinary responses to single dose combinations of captopril and diuretics in conscious spontaneously hypertensive ratsJ. Pharm. Pharmacol.37(2)105-109(1985)
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