Pilsicainide (hydrochloride) (SUN-1165) 是一种口服活性钠通道阻滞剂和有效的 Ic 类抗心律失常剂。
货号:ajcx25358
CAS:88069-49-2
分子式:C17H24N2O·HCl
分子量：308.9
溶解度:DMF: 20 mg/ml,DMSO: 25 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pilsicainide is a class Ic antiarrhythmic agent.^1,2It shortens action potential duration in canine Purkinje fibers, as well as increases the ratio of the effective refractory period to the duration of action potential in guinea pig atrial muscle strips, when used at a concentration of 10 µg/ml.¹Pilsicainide (3-10 mg/kg) restores sinus rhythm in a canine model of ventricular multifocal arrhythmias.²It also suppresses arrhythmias induced by ouabain or halothane and epinephrine in dogs. Formulations containing pilsicainide have been used in the treatment of supraventricular and ventricular tachycardia.

1.Hattori, Y., Inomata, N., Aisaka, K., et al.Electrophysiological actions of N-(2,6-dimethylphenyl)-8-pyrrolizidine-acetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agentJ. Cardiovasc. Pharmacol.8(5)998-1002(1986) 2.Aisaka, K., Hidaka, T., Inomata, N., et al.N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165): A new potent and long-acting antiarrhythmic agentArzneimittelforschung35(8)1239-1245(1985)