A guanosine analog with diverse biological activities
货号:ajcx25124
CAS:80394-72-5
分子式:C10H12N4O6
分子量：284.2
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Oxanosine is an analog of guanosine that has been found inS. capreolusand has diverse biological activities, including antibacterial, antiviral, and anticancer properties.^1,2It is active against a variety of bacteria, includingS. flexneri,P. mirabilis, andE. coli(MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC₅₀s = 7, 27, and >500 µg/ml, respectively).¹It also inhibits the growth of HeLa human cervical cancer cells (IC₅₀= 32 µg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.²

1.Saito, Y., Nakamura, M., Ohno, T., et al.Syntheses of oxanosine and carbocyclic oxanosine derivatives as anti-HIV agentsJ. Antibiot. (Tokyo)53(3)309-313(2000) 2.Shimada, N., Yagisawa, N., Naganawa, H., et al.Oxanosine, a novel nucleoside from actinomycetesJ. Antibiot. (Tokyo)34(9)1216-1218(1981)