An internal standard for the quantification of tauro-α-muricholic acid
货号:ajcx25004
CAS:N/A
分子式:C26H40D4NO7S·Na
分子量：541.7
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tauro-α-muricholic acid-d₄(TαMCA-d₄) is intended for use as an internal standard for the quantification of TαMCA by GC- or LC-MS. TαMCA is an antagonist of the farnesoid X receptor (FXR; IC₅₀= 28 µM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .¹TαMCA is common in rodents but has also been found in small amounts in human serum.²

1.Sayin, S.I., WahlstrÖm, A., Felin, J., et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistCell Metab.17(2)225-235(2013) 2.GarcÍa-CaÑaveras, J.C., Donato, M.T., Castell, J.V., et al.Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated methodJ. Lipid Res.53(10)2231-2241(2012)