A P2Y14 agonist
货号:ajcx24940
CAS:N/A
分子式:C15H22N2O17P2·2Na [XH2O]
分子量：610.3
溶解度:PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y₁₄receptor (EC₅₀= 0.35 μM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells.¹It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.²

1.Jacobson, K.A., Ivanov, A.A., de Castro, S., et al.Development of selective agonists and antagonists of P2Y receptorsPurinergic Signal.5(1)75-89(2009) 2.Lecca, D., Trincavelli, M.L., Gelosa, P., et al.The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repairPLoS One3(10)(2008)