A prodrug for a potent Aurora B inhibitor
货号:ajcx24932
CAS:722543-50-2
分子式:C26H31FN7O6P·2HCl
分子量：660.5
溶解度:DMSO: 1 mg/mL,DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC₅₀= 0.36 nM).¹AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.^2,3AZD 1152 inhibits tumor xenograft growthin vivo.^4,5

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