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Anagrelide-13C3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Anagrelide-13C3图片
规格:98%
分子量:259.1
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
C7[13C]3H7Cl2N3O
货号:ajcx24746
CAS:N/A
分子式:C7[13C]3H7Cl2N3O
分子量:259.1
溶解度:DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Anagrelide-13C3is intended for use as an internal standard for the quantification of anagrelide by GC- or LC-MS. Anagrelide is an inhibitor of phosphodiesterase 3 (PDE3; IC50= 36 nM for the human platelet enzyme).1It inhibits thrombopoietin-induced megakaryocytopoiesis of isolated human CD34+progenitor cells (IC50= 26 nM).2Anagrelide reduces platelet aggregation induced by ADP, collagen, thrombin, or arachidonic acid in isolated rabbit platelet rich-plasma (EC50s = 0.31, 0.08, 0.18, and 0.1 µg/ml, respectively).3It inhibits platelet thrombus formation in a dog model of electrically induced carotid artery thrombosis when administered at doses ranging from 0.5 to 5 mg/kg.4Formulations containing anagrelide have been used in the treatment of thrombocythemia.


1.Wang, G., Franklin, R., Hong, Y., et al.Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell culturesBr. J. Pharmacol.146(3)324-332(2005) 2.Hong, Y., Wang, G., Gutierrez del Arroyo, A., et al.Comparison between anagrelide and hydroxycarbamide in their activities against haematopoietic progenitor cell growth and differentiation: Selectivity of anagrelide for the megakaryocytic lineageLeukemia20(6)1117-1122(2006) 3.Fleming, J.S., and Buyniski, J.P.A potent new inhibitor of platelet aggregation and experimental thrombosis, anagrelide (BL-4162A)Thromb. Res.15(3-4)373-388(1979) 4.Fleming, J.S., and Buyniski, J.P.AnagrelideNew drugs annual: Cardiovascular drugs277-294(1983)