An active metabolite of ibrutinib
货号:ajcx24152
CAS:1654820-87-7
分子式:C25H26N6O4
分子量：474.5
溶解度:Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .¹PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A.

1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et al.Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: Application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.107151-158(2015)