An active metabolite of glyburide
货号:ajcx24090
CAS:23155-00-2
分子式:C23H28ClN3O6S
分子量：510
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/K_ir6.2 sulfonylurea inhibitor glyburide .^1,2It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9.¹rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/K_ir6.2 with IC₅₀values of 0.95 and 100 nM, respectively.²

1.Zharikova, O.L., Fokina, V.M., Nanovskaya, T.N., et al.Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburideBiochem. Pharmacol.78(12)1483-1490(2009) 2.Hill, R.A., Rudra, S., Peng, B., et al.Hydroxyl-substituted sulfonylureas as potent inhibitors of specific [3H]glyburide binding to rat brain synaptosomesBioorg. Med. Chem.11(9)2099-2113(2003)