| 包装: | 500ug |
| 规格: | 98% |
| 市场价: | 3689元 |
| 分子量: | 826 |
Background:
Rifampicin-d3is intended for use as an internal standard for the quantification of rifampicin by GC- or LC-MS. Rifampicin is a rifamycin antibiotic and inhibitor of bacterial RNA polymerase (IC50= 0.01 μg/ml for theE. colienzyme).1It inhibits the growth ofM. tuberculosisH37Rv in mouse peritoneal macrophages (MIC = 0.8 μg/ml) as well as clinical isolates of various species ofStaphylococcus,Streptococcus,Haemophilus, andNeisseria(MICs = 0.009-1.4 μg/ml).2,3Rifampicin increases survival in a mouse model of tuberculosis infection.3It is also an agonist of the human pregnane X receptor (PXR; EC50= ~2 μM).4Formulations containing rifampicin have been used in the treatment of tuberculosis and meningococcal carriers.
1.Wehrli, W.Rifampin: Mechanisms of action and resistanceRev.Infect.Dis.5(3)S407-S411(1983) 2.Jhamb, S.S., Goyal, A., and Singh, P.P.Determination of the activity of standard anti-tuberculosis drugs against intramacrophage Mycobacterium tuberculosis, in vitro: MGIT 960 as a viable alternative for BACTEC 460Braz. J. Infect. Dis.18(3)336-340(2014) 3.Arioli, V., Berti, M., Carniti, G., et al.Antibacterial activity of DL 473, a new semisynthetic rifamycin derivativeJ. Antibiot. (Tokyo)34(8)1026-1032(1981) 4.Gill, S.K., Xu, H., Kirchhoff, P.D., et al.Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerasesJournal of Medicinal Chemistry55(8)3814-3826(2012)
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