规格: | 98% |
分子量: | 396.6 |
包装 | 价格(元) |
100ug | 电议 |
500ug | 电议 |
1mg | 电议 |
5mg | 电议 |
Background:
Prostaglandin E1isopropyl ester is an ester prodrug form of prostaglandin E1with enhanced lipid solubility.1,2The ester functional group on PGE1isopropyl ester is readily hydrolyzed in cells andin vivoto release active PGE1.1PGE1isopropyl ester exhibits a faster penetration flux than the free acid form of PGE1when applied topically to isolated mouse skin. Topical administration of PGE1isopropyl ester (1 mM) reduces fluid pressure within human dermal fibroblast cell aggregates.2
1.Ho, H.O., Hwang, M.C., Tseng, S.L., et al.The percutaneous penetration of prostaglandin E1 and its alkyl estersJ. Control Release58(3)349-355(1999) 2.Stuhr, L.E., Reith, A., LepsØe, S., et al.Fluid pressure in human dermal fibroblast aggregates measured with micropipettesAm. J. Physiol. Cell Physiol.285(5)C1101-1108(2003)