规格: | 98% |
分子量: | 464.4 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Background:
MitoP-d15is intended for use as an internal standard for the quantification of MitoP by GC- or LC-MS. MitoP is a phenol product produced by the reaction of H2O2with the ratiometric mass spectrometry probe MitoB . MitoB contains a triphenylphosphonium cation component that drives its accumulation in mitochondria where its arylboronic moiety selectively reacts with H2O2to produce MitoP.1,2Quantifying the MitoP/MitoB ratio by LC-MS/MS reflects the mitochondrial matrix H2O2concentration.
1.CochemÉ, H.M., Quin, C., McQuaker, S.J., et al.Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrixCell Metabolism13(3)340-350(2011) 2.CochemÉ, H.M., Logan, A., Prime, T.A., et al.Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living DrosophilaNature Protocols7(5)946-958(2012)