An internal standard for the quantification of bimatoprost (free acid)
货号:ajcx21154
CAS:58976-50-4
分子式:C23H28D4O5
分子量：392.5
溶解度:DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): .5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

17-phenyl trinor Prostaglandin F_2α-d₄(17-phenyl trinor PGF_2α-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF_2αby GC-or LC-mass spectrometry. 17-phenyl trinor PGF_2αis a metabolically stable analog of PGF_2αand is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF_2α.¹At the rat recombinant FP receptor expressed in CHO cells 17-phenyl trinor PGF_2αinhibits PGF_2αbinding with a K_iof 1.1 nM.²The isopropyl ester of 17-phenyl trinor PGF_2α-d₄is slightly better than PGF_2αisopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.³

1.Balapure, A.K., Rexroad, C.E., Jr., Kawada, K., et al.Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptorBiochem. Pharmacol.38(14)2375-2381(1989) 2.Lake, S., Gullberg, H., Wahlqvist, J., et al.Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptorFEBS Letters355317-325(1994) 3.Stjernschantz, J., and Resul, B.Phenyl substituted prostaglandin analogs for glaucoma treatmentDrugs of the Future17691-704(1992)