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CINPA1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CINPA1图片
规格:98%
分子量:395.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
CINPA1 是一种有效且特异性的组成型雄甾烷受体 (CAR) 抑制剂,不会激活孕烷 X 受体 (PXR)。
货号:ajcx20176
CAS:102636-74-8
分子式:C23H29N3O3
分子量:395.5
溶解度:DMSO: 100 mM,Ethanol: 100 mM
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CINPA1 is a constitutive androstane receptor (CAR) antagonist (IC50 = 70 nM in a reporter assay).1 It is selective for CAR over the nuclear receptors GR, FXR, LXRα, LXRβ, PPARγ, RXRα, and RXRβ at 18 μM, but also antagonizes the human pregnane X receptor (PXR; IC50 = 6.6 μM). CINPA1 (0.3-5 μM) inhibits CAR transactivation of CYP2B6 induced by CITCO in primary human hepatocytes.


|1. Cherian, M.T., Lin, W., Wu, J., et al. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol. Pharmacol. 87(5), 878-889 (2015).