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Isosorbide Dinitrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Isosorbide Dinitrate图片
规格:98%
分子量:236.1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
硝酸异山梨酯 (ISDN) 是一种 NO 供体,可防止心肌梗死 (MI) 后 LV 重塑和心脏功能退化。
货号:ajcx19486
CAS:87-33-2
分子式:C6H8N2O8
分子量:236.1
溶解度:Chloroform: Slightly Soluble,Methanol: Slightly Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.1 It induces vasodilation with IC50 values of 0.56 and 1.82 μM for isolated precontracted rabbit femoral vein and artery, respectively.2 Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model.3 It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range.4 Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.

参考文献
1. Ahlner, J., Andersson, R.G., Torfgard, K., et al. Organic nitrate esters: Clinical use and mechanisms of actions. Pharmacol. Rev. 43(3), 351-423 (1991).
2. Toyoda, J., Hisayama, T., and Takayanagi, I. Nitro compounds (isosorbide dinitrate, 5-isosorbide mononitrate and glyceryl trinitrate) on the femoral vein and femoral artery. Gen. Pharmacol. 17(1), 89-91 (1986).
3. Jordan, B.F., Misson, P., Demeure, R., et al. Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: Monitoring by EPR and MRI. Int. J. Radiat. Oncol. Biol. Phys. 48(2), 565-570 (2000).
4. De Caterina, R., Giannessi, D., Bernini, W., et al. Organic nitrates: Direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates. Thromb. Haemost. 59(2), 207-211 (1988).