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Dextromethorphan-d3(CRM)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dextromethorphan-d3(CRM)图片
包装:1mg
规格:98%
市场价:1646元
分子量:274.4

产品介绍
C18H22D3NO
货号:ajcx19372
CAS:524713-56-2
分子式:C18H22D3NO
分子量:274.4
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dextromethorphan-d3 (CRM) contains three deuterium atoms at the 17-methyl group. It is intended for use as an internal standard for the quantification of dextromethorphan by GC- or LC-mass spectrometry. Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, DXM is widely used as a cough suppressant.1 However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).1,2,3 DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.1,4

参考文献
1. Weinbroum, A.A., Rudick, V., Paret, G., et al. The role of dextromethorphan in pain control. Can.J.Anesth. 47(6), 585-596 (2000).
2. Damaj, M.I., Flood, P., Ho, K.K., et al. Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: In vitro and in vivo selectivity. Journal of Pharmacology and Experimental Therapeutics 312(2), 780-785 (2005).
3. Netzer, R., Pflimlin, P., and Trube, G. Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons. European Journal of Pharmacology 238, 209-216 (1993).
4. Chen, Y.W., Chu, K.S., Lin, C.N., et al. Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats. Anesthesia and Analgesia 104(5), 1251-1255 (2007).