您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Etilevodopa hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Etilevodopa hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Etilevodopa hydrochloride图片
规格:98%
分子量:261.7
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Etilevodopa (L-Dopa ethyl ester) hydrochloride 是 Levodopa 的前药,在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa hydrochloride 用于治疗帕金森病 (PD)。Levodopa 是多巴胺的直接前体,是一种合适的前体药物,有助于中枢神经系统的渗透和传递多巴胺。
货号:ajcx17244
CAS:39740-30-2
分子式:C11H16ClNO4
分子量:261.7
溶解度:H2O: 125 mg/mL (477.65 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine[1][2][3].


[1]. Djaldetti R, et al. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson's disease: an open-label, randomized, crossover study. Clin Neuropharmacol. 2003 Nov-Dec;26(6):322-6. [2]. Blindauer K, et al. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. Arch Neurol. 2006 Feb;63(2):210-6. [3]. Haddad F, et al. Dopamine and Levodopa Prodrugs for the Treatment of Parkinson's Disease. Molecules. 2017 Dec 25;23(1). pii: E40.