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Dichlorophenyl-ABA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dichlorophenyl-ABA图片
规格:98%
分子量:282.12
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Dichlorophenyl-ABA 是转甲状腺素蛋白 (TTR) 淀粉样蛋白原纤维形成的抑制剂,可抑制表达 TTR L55P 的细胞中 80% 以上的聚集体形成。
货号:ajcx15324
CAS:18201-65-5
分子式:C13H9Cl2NO2
分子量:282.12
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells[1].

Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are[1]. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity[1].


[1]. Cardoso I, et al. Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design. Biochem J. 2007 Nov 15;408(1):131-8.