ACBI1 是一种有效的，基于 PROTAC 技术的 BAF ATPase 亚基 SMARCA2 和 SMARCA4 降解剂，也是 PBAF 成员 PBRM1 的降解剂, 对 SMARCA2、SMARCA4 和 PBRM1 作用的 DC50 值分别为 6 nM、11 nM 和 32 nM。ACBI1 由一个 bromodomain 配体、linker 和 E3 泛素连接酶 VHL 构成，能诱导抗增殖作用和凋亡。
货号:ajcx13690
CAS:N/A
分子式:C49H58FN9O7S
分子量：936.1
溶解度:DMSO: ≥ 100 mg/mL (106.83 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis[1]. DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)[1]

[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.