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Euparin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Euparin图片
规格:98%
分子量:216.23
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Euparin 是苯并呋喃的单体化合物,是一种活性氧 (ROS) 抑制剂。 Euparin 对脊髓灰质炎病毒具有抗病毒活性,并且还具有抗抑郁作用。
货号:ajcx39652
CAS:532-48-9
分子式:C13H12O3
分子量:216.23
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2].

In Vero cells, Euparin shows antiviral activity against poliovirus types 1, 2, and 3 with EC50 values of 0.47 µg/mL, 0.12 µg/mL, and 0.15 µg/mL, respectively[1].

Euparin (8, 16 and 32 mg/kg) reduces depression-like behavior in Chronic Unpredictable Mild Stress (CUMS) model of mice. All doses of Euparin are found to increase the contents of monoamine neurotransmitter and decrease monoamine oxidase and reactive oxygen species (ROS) levels in brain of depression mice. Euparin restores CUMS-induced decrease of Spermidine/Spermine N1-Acetyltransferase 1 (SAT1), N-methyl-D-aspartate receptor subtype 2B (NMDAR2B) and brain derived neurotrophic factor (BDNF) expression[2].

[1]. arÍa Florencia Visintini Jaime, et al. Antipoliovirus Activity of the Organic Extract of Eupatorium buniifolium: Isolation of Euparin as an Active Compound. Evid Based Complement Alternat Med. 2013;2013:402364.
[2]. Xu-Meng Han, et al. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1/NMDAR2B/BDNF Signal Pathway. Biol Pharm Bull. 2020 Oct 1;43(10):1490-1500.