JAK-IN-3 (compound 22) 是一种有效的 JAK 抑制剂,其对 JAK3、JAK1、TYK2 和JAK2 的 IC50 值分别为 3 nM、5 nM、34 nM 和 70 nM。
货号:ajcx39608
CAS:1400876-94-9
分子式:C18H20N4O3
分子量:340.38
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:
现货Background:
JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively[1].
[1]. Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10(3):306-311.
Protocol:
JAK3 3nM(IC50) | JAK1 5nM(IC50) | Tyk2 34nM(IC50) | JAK2 70nM(IC50) |