CDK9-IN-13 (化合物 38) 是一种有效和选择性的 CDK 抑制剂，IC50 值<3 nm。cdk9-in-13 在啮齿动物中的半衰期很短。
货号:ajcx39236
CAS:N/A
分子式:C27H35N5O2
分子量：461.6
溶解度:DMSO : 2.5 mg/mL (5.42 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CDK9-IN-13 (compound 38) is potent and selective CDK9 inhibitor, with an IC50 of<3 nM. CDK9-IN-13 exhibits short half-lives in rodents[1].

[1]. Barlaam B, et, al. Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J Med Chem. 2021 Oct 28;64(20):15189-15213.

Protocol:

CDK9 <3nM(IC50)

CDK1 0.14μM(IC50)

CDK2 0.72μM(IC50)

CDK7 0.40μM(IC50)

CDK12 0.055μM(IC50)